Hops' signature terpene — appetite-suppressing, anti-inflammatory, and antibacterial.
Humulene is the primary terpene in hops (Humulus lupulus) and gives beer its characteristic hoppy aroma. In cannabis, it is notable for being one of the few terpenes associated with appetite suppression rather than stimulation — making it relevant for weight management. It also demonstrates potent anti-inflammatory and antibacterial properties.
Aroma Profile
Primary Effects
Also Found In
Hops, Coriander, Cloves, Basil
Inhibits prostaglandin E2 synthesis, reducing inflammation and pain through a COX-independent pathway.
Induces apoptosis in cancer cell lines via mitochondrial pathway, with synergistic effects when combined with chemotherapy agents.
May partially antagonize CB1 receptors, counteracting the appetite-stimulating effects of THC. Mechanism requires further characterization.
Humulene often co-occurs with caryophyllene and contributes to the anti-inflammatory profile of many cannabis strains. The combination of humulene + caryophyllene is associated with the strongest anti-inflammatory effects in the terpene literature.
Inflammation
Moderate EvidenceInhibits PGE2 synthesis and reduces inflammatory markers. Comparable to some NSAIDs in preclinical models.
Condition guideCancer (adjunct)
Preliminary EvidenceInduces apoptosis in cancer cell lines and demonstrates synergy with chemotherapy agents in preclinical models.
Condition guideObesity / Appetite
Preliminary EvidenceOne of the few terpenes associated with appetite suppression. Mechanism not fully characterized but may involve CB1 partial antagonism.
Condition guideAnti-inflammatory and analgesic effects of humulene
Humulene reduced carrageenan-induced paw edema by 32% and demonstrated analgesic effects comparable to indomethacin in rodent models.
Humulene induces apoptosis in cancer cells
Humulene induced apoptosis in HeLa and MCF-7 cancer cell lines with IC50 values of 28 and 35 μM respectively, with minimal toxicity to normal cells.
Girl Scout Cookies
Hybrid
Headband
Hybrid
Skywalker OG
Indica
White Widow
Hybrid
Sour Diesel
Sativa
GRAS status. Safe at cannabis concentrations. No significant drug interactions documented.
All terpene information is for educational purposes only. Consult a healthcare provider before using cannabis therapeutically.